Identification of the Apoptosis and Autophagy Bi-functional Proteins
发表时间：2019-07-01
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- 论文类型：
- 期刊论文
- 第一作者：
- Wang Peiran
- 合写作者：
- Zhang Zhichao
- 发表时间：
- 2019-05-23
- 发表刊物：
- Molecular informatics
- 收录刊物：
- PubMed
- 文献类型：
- J
- ISSN号：
- 1868-1751
- 关键字：
- PPI network analysis,apoptosis,autophagy,bi-functional proteins
- 摘要：
- Although autophagy and apoptosis, two main kinds of programmed cell death, constitute distinct cellular processes with often opposing outcomes, there have been shown a complex interplay between them in recent years. This interplay is surely critical to the overall fate of the cell. However, a full-scale identification of those bi-functional proteins involved in both functions is currently beyond reach by existing databases or traditional biological experiments. And that makes the interplay impossible to be well understood. Here we built a large, comprehensiveness apoptosis and autophagy related PPI (protein-protein interaction) network and then used topology clustering to undergo a network analysis workflow. Finally, we concluded a list of 151 apoptosis and autophagy bi-functional proteins from this network. By this way we showed a global view on these bi-functional proteins about their unique characteristics and provided clues of new functions of some proteins which are not focused in present researches.© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
- 是否译文：
- 否
