Indexed by:
期刊论文
First Author:
Zhu, Wenjia
Correspondence Author:
Huo, L (reprint author), Beijing Union Med Coll Hosp, Dept Nucl Med, 1 Shuaifuyuan, Beijing, Peoples R China.
Co-author:
Wang, Hongkai,Li, Zibo,Wu, Zhanhong,Zhu, Zhaohui,Li, Fang,Huo, Li,Yao, Shaobo,Xing, Haiqun,Zhang, Hui,Tai, Yuan-chuan,Zhang, Yingqiang,Liu, Yimin,Ma, Yanru,Wu, Chenxi
Date of Publication:
2016-10-01
Journal:
MOLECULAR IMAGING AND BIOLOGY
Included Journals:
SCIE、PubMed、Scopus
Document Type:
J
Volume:
18
Issue:
5
Page Number:
782-787
ISSN No.:
1536-1632
Key Words:
[F-18] FDS; Biodistribution; Radiation dosimetry; Enterobacteriaceae;
PET
Abstract:
[F-18]fluorodeoxysorbitol ([F-18]FDS) is the first radiopharmaceutical specific for a category of bacteria and has the potential to specifically detect Enterobacteriaceae infections. The purpose of this study was to testify the safety and investigate the biodistribution and radiation dosimetry of [F-18]FDS in healthy human bodies.
Six healthy subjects were intravenously injected with 320-520 MBq [F-18]FDS. On each subject, 21 whole-body emission scans and a brain scan were conducted at settled time points within the next 4 h. Residence time for each source organ was determined by multi-exponential regression. Absorbed doses for target organs and effective dose were calculated via OLINDA/EXM.
No adverse events due to [F-18]FDS injection were observed in the study. The tracer was cleared rapidly from the blood pool through the urinary system. A small portion was cleared into the gut through the hepatobiliary system. The effective dose (ED) was estimated to be 0.021 +/- 0.001 mSv/MBq. The organ receiving the highest absorbed dose was the urinary bladder wall (0.25 +/- 0.03 mSv/MBq).
[F-18]FDS is safe and well tolerated. The effective dose was comparable to that of other F-18 labeled radiotracers. [F-18]FDS is suitable for human use from a radiation dosimetry perspective.
Translation or Not:
no
