Biodistribution and Radiation Dosimetry of the Enterobacteriaceae-Specific Imaging Probe [F-18]Fluorodeoxysorbitol Determined by PET/CT in Healthy Human Volunteers
发表时间：2019-03-13
点击次数：
- 论文类型：
- 期刊论文
- 第一作者：
- Zhu, Wenjia
- 通讯作者：
- Huo, L (reprint author), Beijing Union Med Coll Hosp, Dept Nucl Med, 1 Shuaifuyuan, Beijing, Peoples R China.
- 合写作者：
- Wang, Hongkai,Li, Zibo,Wu, Zhanhong,Zhu, Zhaohui,Li, Fang,Huo, Li,Yao, Shaobo,Xing, Haiqun,Zhang, Hui,Tai, Yuan-chuan,Zhang, Yingqiang,Liu, Yimin,Ma, Yanru,Wu, Chenxi
- 发表时间：
- 2016-10-01
- 发表刊物：
- MOLECULAR IMAGING AND BIOLOGY
- 收录刊物：
- SCIE、PubMed、Scopus
- 文献类型：
- J
- 卷号：
- 18
- 期号：
- 5
- 页面范围：
- 782-787
- ISSN号：
- 1536-1632
- 关键字：
- [F-18] FDS; Biodistribution; Radiation dosimetry; Enterobacteriaceae; PET
- 摘要：
- [F-18]fluorodeoxysorbitol ([F-18]FDS) is the first radiopharmaceutical specific for a category of bacteria and has the potential to specifically detect Enterobacteriaceae infections. The purpose of this study was to testify the safety and investigate the biodistribution and radiation dosimetry of [F-18]FDS in healthy human bodies. Six healthy subjects were intravenously injected with 320-520 MBq [F-18]FDS. On each subject, 21 whole-body emission scans and a brain scan were conducted at settled time points within the next 4 h. Residence time for each source organ was determined by multi-exponential regression. Absorbed doses for target organs and effective dose were calculated via OLINDA/EXM. No adverse events due to [F-18]FDS injection were observed in the study. The tracer was cleared rapidly from the blood pool through the urinary system. A small portion was cleared into the gut through the hepatobiliary system. The effective dose (ED) was estimated to be 0.021 +/- 0.001 mSv/MBq. The organ receiving the highest absorbed dose was the urinary bladder wall (0.25 +/- 0.03 mSv/MBq). [F-18]FDS is safe and well tolerated. The effective dose was comparable to that of other F-18 labeled radiotracers. [F-18]FDS is suitable for human use from a radiation dosimetry perspective.
- 是否译文：
- 否
