MICROENCAPSULATION OF ASTAXANTHIN IN ALGINATE USING MODIFIED EMULSION TECHNOLOGY: PREPARATION, CHARACTERIZATION, AND CYTOSTATIC ACTIVITY
发表时间：2019-03-12
点击次数：
- 论文类型：
- 期刊论文
- 第一作者：
- Zhang, Xiujuan
- 通讯作者：
- He, GH (reprint author), Dalian Univ Technol, Sch Petr & Chem Engn, State Key Lab Fine Chem, Panjin 124221, Peoples R China.; He, GH (reprint author), Dalian Univ Technol, Sch Chem Engn, R&D Ctr Membrane Sci & Technol, Dalian 116024, Peoples R China.
- 合写作者：
- Yin, Wenjuan,Qi, Yankai,Li, Xiangcun,Zhang, Wenjun,He, Gaohong
- 发表时间：
- 2017-03-01
- 发表刊物：
- CANADIAN JOURNAL OF CHEMICAL ENGINEERING
- 收录刊物：
- SCIE、EI
- 文献类型：
- J
- 卷号：
- 95
- 期号：
- 3
- 页面范围：
- 412-419
- ISSN号：
- 0008-4034
- 关键字：
- astaxanthin; calcium alginate; encapsulation efficiency; uniform size distribution; cytostatic activity
- 摘要：
- In the present study, astaxanthin was microencapsulated in a biodegradable material, calcium alginate, using a modified emulsion technology developed at our laboratory. The modified emulsion method involves the reaction between a sodium alginate emulsion and a calcium chloride emulsion. After mixing these emulsions, Ca2+ penetrates two oil-water layers to combine -COO-, and microparticles are formed with narrow size distribution and good dispersion due to the mild reaction speed. The microencapsulated astaxanthin showed much higher storage stability and antioxidant activity than the non-encapsulated astaxanthin. Cytostatic activity was preliminarily evaluated on adipose-derived stem cells, the microencapsulated astaxanthin showed significant cytostatic activity due to the improved solubility of astaxanthin caused by the good biocompatibility of calcium alginate. Characterization confirmed the existence of microparticles with high encapsulation efficiency (more than 85%), uniform size distribution (1.61 mu m), and sustained astaxanthin release, suggesting the prepared microparticles by the modified emulsion method have great potential in pharmaceutical, food, and cosmetic industries.
- 是否译文：
- 否
