Citric acid-loaded W-1/O/W-2 multiple emulsions efficiently remove colonic ammonia both in vitro and in vivo
发表时间：2019-03-12
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- 论文类型：
- 期刊论文
- 第一作者：
- Bian, Tengfei
- 通讯作者：
- He, GH (reprint author), State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Liaoning Provin, Peoples R China.
- 合写作者：
- Zhang, Xiujuan,He, Gaohong,Duan, Zhijun,Dong, Chunxu,Li, Xiangcun,Guo, Nana
- 发表时间：
- 2017-01-02
- 发表刊物：
- JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
- 收录刊物：
- SCIE、EI、Scopus
- 文献类型：
- J
- 卷号：
- 38
- 期号：
- 1
- 页面范围：
- 1-7
- ISSN号：
- 0193-2691
- 关键字：
- Ammonia removal; citric acid; colonic ammonia; Hepatic encephalopathy; W-1/O/W-2 emulsions
- 摘要：
- Hepatic encephalopathy (HE) is a neuropsychiatric disorder caused by chronic and acute liver diseases. It is believed that ammonia played an important role on the pathogenesis of the disease. Herein, acid-loaded water-in-oil-in-water (W-1/O/W-2) multiple emulsions with over 95% encapsulation efficiency were prepared and used to absorb colonic ammonia. The study of citric acid release from W-1 to W-2 in bulk deionized water indicated that only 17% acid released in 8 hours, which proved the stability of the multiple emulsions and hence prevented the intestine from being irritated by acid burst release. In vitro, the W-1/O/W-2 emulsion could remove around 90% ammonia in 1.5 hours from either the 3mmol/L ammonia solution or the artificial colonic fluid with 1 and 0.5mmol/L ammonia without acidifying the artificial colonic fluid. In vivo, compared with lactulose, W-1/O/W-2 emulsions could efficiently reduce the blood ammonia to the similar level in the rat models with HE without increasing the water content in feces. All these results indicated a potential application of W-1/O/W-2 multiple emulsions for the treatment of HE.
- 是否译文：
- 否
