Indexed by:
期刊论文
First Author:
Bian, Tengfei
Correspondence Author:
He, GH (reprint author), State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Liaoning Provin, Peoples R China.
Co-author:
Zhang, Xiujuan,He, Gaohong,Duan, Zhijun,Dong, Chunxu,Li, Xiangcun,Guo, Nana
Date of Publication:
2017-01-02
Journal:
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Included Journals:
SCIE、EI、Scopus
Document Type:
J
Volume:
38
Issue:
1
Page Number:
1-7
ISSN No.:
0193-2691
Key Words:
Ammonia removal; citric acid; colonic ammonia; Hepatic encephalopathy;
W-1/O/W-2 emulsions
Abstract:
Hepatic encephalopathy (HE) is a neuropsychiatric disorder caused by chronic and acute liver diseases. It is believed that ammonia played an important role on the pathogenesis of the disease. Herein, acid-loaded water-in-oil-in-water (W-1/O/W-2) multiple emulsions with over 95% encapsulation efficiency were prepared and used to absorb colonic ammonia. The study of citric acid release from W-1 to W-2 in bulk deionized water indicated that only 17% acid released in 8 hours, which proved the stability of the multiple emulsions and hence prevented the intestine from being irritated by acid burst release. In vitro, the W-1/O/W-2 emulsion could remove around 90% ammonia in 1.5 hours from either the 3mmol/L ammonia solution or the artificial colonic fluid with 1 and 0.5mmol/L ammonia without acidifying the artificial colonic fluid. In vivo, compared with lactulose, W-1/O/W-2 emulsions could efficiently reduce the blood ammonia to the similar level in the rat models with HE without increasing the water content in feces. All these results indicated a potential application of W-1/O/W-2 multiple emulsions for the treatment of HE.
Translation or Not:
no
