Indexed by:
期刊论文
First Author:
Wang Xing-yong
Correspondence Author:
Cui, JN (reprint author), Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China.
Co-author:
Cui Jing-nan,Ren Wei-min,Zhao Guo-quan,Li Feng,Qian Xu-hong
Date of Publication:
2010-11-01
Journal:
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
Included Journals:
SCIE、ISTIC、CSCD、Scopus
Document Type:
J
Volume:
26
Issue:
6
Page Number:
981-985
ISSN No.:
1005-9040
Key Words:
Liver microsome; Reduction; Nitroaromatic compound; Aromatic
hydroxylamine
Abstract:
Nitroaromatic compounds were reductively metabolized to the corresponding amine compounds via the intermediate hydroxylamines by liver microsomes from pig, rat, chook, cattle, sheep, paralichthys olivaceus and cyprinoid in varied reactivity. Similar with baker's yeast, the pig, rat and sheep liver microsomes exhibited high reactivity toward 4-nitro-1,2-dicyanbenzen(1a), while the cyprinoid liver microsomes were inefficient. Contrasted to compound la, monocyannitrobenzene(2a) was difficult to reduce by pig liver microsomes. In opposition to grape cells, pig liver microsomes exhibited activities toward some aromatic hydroxylamine compounds.
Translation or Not:
no
