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基于Virtools的氨合成塔模拟及虚拟系统构建
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Ni and Co doped yolk-shell type Fe2O3 hollow microspheres as anode materials for lithium-ion batteries
双乳化-凝胶法制备单分散海藻酸钙微球及其载BSA研究
Release time:2019-03-12
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会议论文
First Author:
赵志娟
Co-author:
贺高红,李祥村,边腾飞
Date of Publication:
2012-07-20
Document Type:
A
Page Number:
501-505
Key Words:
海藻酸钙微球;牛血清白蛋白;双乳化-凝胶法;体外释放性能
Abstract:
采用双乳化凝胶法制备了单分散的海藻酸钙凝胶微球，并通过正交试验系统考察了海藻酸钠浓度、氯化钙浓度、表面活性剂浓度、搅拌速度和油水比对海藻酸钙凝胶微球粒径及形貌的影响。在优化的条件下，制备出了平均粒径为4舯1、单分散和球形度好的海藻酸钙凝胶微球。包埋模型药物牛血清白蛋白(BSA)的过程中，以去离子水作为洗涤液洗涤海藻酸钙微球时，BSA的包封率仅为13％左右；当水洗液的pH值为3.2时，BsA的包封率提高到66％左右，载药率可达16％，这是海藻酸钙pH值响应溶胀和BSA与海藻酸盐之间静电作用的结果。微球中盼气的体外释放曲线表明，该系统具有在模拟胃液中释药速率慢、释药量低、模拟肠液中释药迅速的特性。因此，双乳化-凝胶法制备海藻酸钙微球有望成为制备蛋白类药物控释制剂的一种新方法，以达到靶向快速给药的目的。
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