Journal of Medicinal Chemistry: Exploiting the “Hot-Spots” of Hsp70–Bim Protein–Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70–Bim Inhibitors2023-11-27 Cellular & Molecular Biology Letters: Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex2023-05-26 Biochemical Pharmacology: Bcr-Abl drives the formation of Hsp70/Bim PPI to stabilize oncogenic clients and prevent cells from undergoing apoptosis2022-08-16 Analytical Chemistry: Discovery of a fluorogenic probe for in situ pyruvate kinase M2 iso-form (PKM2) labeling through chemoselective SNAr with a binding site lysine residue2021-08-06 Biochemical Pharmacology: Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis2021-06-18 Leukemia: Small-molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance2021-06-04 EUR J MED CHEM：A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction2021-03-29 ChemBioChem (COVER): A “three-in-one” multi-functional probe for Bcl-2/Mcl-1 profiling and visualizing in situ2021-03-15 Journal of Medicinal Chemistry: Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-22020-12-09 Journal of Biological Chemistry: The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients2020-07-12