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Zhichao Zhang
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Zhichao Zhang
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Journal of Medicinal Chemistry:Discovery of Biphenyl Derivatives to Target Hsp70-Bim Protein-Protein Interaction in Chronic Myeloid Leukemia by Scaffold Hopping Strategy
2024-07-16
Journal of Medicinal Chemistry: Exploiting the “Hot-Spots” of Hsp70–Bim Protein–Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70–Bim Inhibitors
2023-11-27
Cellular & Molecular Biology Letters: Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex
2023-05-26
Biochemical Pharmacology: Bcr-Abl drives the formation of Hsp70/Bim PPI to stabilize oncogenic clients and prevent cells from undergoing apoptosis
2022-08-16
Analytical Chemistry: Discovery of a fluorogenic probe for in situ pyruvate kinase M2 iso-form (PKM2) labeling through chemoselective SNAr with a binding site lysine residue
2021-08-06
Biochemical Pharmacology: Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis
2021-06-18
Leukemia: Small-molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance
2021-06-04
EUR J MED CHEM:A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction
2021-03-29
ChemBioChem (COVER): A “three-in-one” multi-functional probe for Bcl-2/Mcl-1 profiling and visualizing in situ
2021-03-15
Journal of Medicinal Chemistry: Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2
2020-12-09
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